A modified CB1-receptor agonist for analgesia without adverse effects.
Category: biotech/medical – Page 284
Gut Microbe Composition During Infancy May Protect Against Diabetes in Later Life
Scientists headed by a team at the University of Utah Health have reported on research in mice suggesting that microbiome composition during infancy can shape development of pancreatic insulin-producing cells, leading to long-term changes in metabolism and impacting on diabetes risk later in life. The study, reported in Science by research co-lead June Round, PhD, professor of pathology at University of Utah Health, and colleagues, identified what the team describes as “a critical neonatal window in mice when microbiota disruption results in lifelong metabolic consequences stemming from reduced β cell development.”
Round suggests that understanding how the microbiome impacts metabolism could potentially lead to microbe-based treatments to prevent type 1 diabetes. “What I hope will eventually happen is that we’re going to identify these important microbes, and we’ll be able to give them to infants so that we can perhaps prevent this disease from happening altogether.”
In their published paper, titled “Neonatal fungi promote lifelong metabolic health through macrophage-dependent β cell development,” the team concluded that their results “… identify fungi as critical early-life commensals that promote long-term metabolic health …”
Wires in The Brain
Rodolfo Llinas tells the story of how he has developed bundles of nanowires thinner than spider webs that can be inserted into the blood vessels of human brains.
While these wires have so far only been tested in animals, they prove that direct communication with the deep recesses of the brain may not be so far off. To understand just how big of a breakthrough this is—US agents from the National Security Agency quickly showed up at the MIT laboratory when the wires were being developed.
What does this mean for the future? It might be possible to stimulate the senses directly — creating visual perceptions, auditory perceptions, movements, and feelings. Deep brain stimulation could create the ultimate virtual reality. Not to mention, direct communication between man and machine or human brain to human brain could become a real possibility.
Llinas poses compelling questions about the potentials and ethics of his technology.
Researchers discover the brain cells that tell you to stop eating
Newly discovered brain cells count each bite before sending the order to cease eating a meal. Columbia scientists have found specialized neurons in the brains of mice that order the animals to stop eating.
Though many feeding circuits in the brain are known to play a role in monitoring food intake, the neurons in those circuits do not make the final decision to cease eating a meal.
The neurons identified by the Columbia scientists, a new element of these circuits, are located in the brainstem, the oldest part of the vertebrate brain. Their discovery could lead to new treatments for obesity.
Woman’s Heartwarming Story About Beating Stage 4 Cancer With Herbs Sparks Debate
A viral video featuring a woman who credits sour sop leaves, apricot seeds, and dietary changes for overcoming stage 4 metastatic breast cancer has ignited widespread discussion on social media.
Originally shared by Super Food Mood on Instagram, the video has amassed significant traction, drawing both support and skepticism.
A Survivor’s Testimony
Free Radicals Extend Lifespan?
In this edition, we’ll take a look at a Canadian study which shows that reducing a worm’s ability to fight free radicals in a specific organ could increase it’s lifespan. Does this have any implications for humans?
Contents:
Intro 0:00
Graphical Abstract 1:49
Figure 1. Tissue-specific re-expression of sod-2 rescues deficits in fertility and embryonic lethality in clk-1;sod-2 mutants 2:28
Figure 2. Tissue-specific re-expression of sod-2 can decrease stress resistance in clk-1;sod-2 worms 5:37
Figure 3. Tissue-specific re-expression of sod-2 is not sufficient to reduce clk-1;sod-2 lifespan 6:41
Figure 4. Disruption of mitochondrial superoxide dismutase in the intestine is sufficient to increase lifespan 7:33
Figure 5. Intestine-specific knockdown of sod-2 is sufficient to enhance resistance to heat stress 9:33
Figure 6. Intestine-specific knockdown of sod-2 does not affect physiologic rates 10:29
Conclusion & Next Steps 11:40
Study reviewed:
Intestine-specific disruption of mitochondrial superoxide dismutase extends longevity.
https://www.sciencedirect.com/science/article/pii/S0891584925000383
2009 paper from the same authors:
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans.
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.
General overview of the pros and cons of free radicals for lifespan:
Reversing Senescence with Exosomes
Introducing a new weekly video series showcasing the latest impactful longevity related studies.
” +Study reviewed: Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.
A new weekly series showcasing the latest and most impactful longevity studies.
In this first edition, we’ll take a look at how a subset of blood stem cells from old mice can be used to rejuvenate the blood & immune systems of other old mice and increase their lifespans.
Study reviewed:
Young Plasma Improves Surgery
Reviewing a trial where young blood plasma was used during joint replacement surgery in older adults, reducing immune system related inflammation and speeding up recovery. This is one of the first human trials of young plasma after many positive results in mice.
Contents:
Intro 0:00
Study Overview 1:07
Proteomic Changes 1:45
Immune Response 3:07
Specific Immune Cell Changes 4:22
Patient Outcomes 6:09
Conclusion 7:44
Study reviewed:
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.
https://translational-medicine.biomedcentral.com/articles/10…45;06215-w.
If you liked this video, please consider supporting its creation via a donation to the Canadian Longevity Association, which will not only help create these videos, but also help our other advocacy and outreach efforts:
https://www.zeffy.com/en-CA/donation-form/c47dd699-b5bd-4d28…26f77ddcf3
Or, order something from our new merchandise shop:
January 2025 Longevity Review
Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen lifespan; how there is a subset of youthful stem cells in older animals which can increase lifespan; the most comprehensive study of life extending molescules in the roundworm; and, in the Canadian content study, how disrupting antioxidant defences in a single organ can extend longevity. https://youtu.be/uiEcPFH0EDk
Kicking off the new year with a lifespan special, we will take a look at reversing the senescence of senescent cells to increase mouse lifespan; the discovery and beneficial effects of a subset of youthful stem cells which can also increase mouse longevity; the most comprehensive study of life-extending molecules in the roundworm c.elegans ; and in the Canadian Content study, how disrupting the antioxidant defences in a specific organ in c.elegans can increase its lifespan.